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However since late 2003, when the FDA banned the sale of ephedra-containing drugs attributable to evidence of elevated threat of heart assault, these formulations have replaced ephedra with a mixture of vitamins (comparable to thiamin, riboflavin, vitamin B-6, folic acid), an ephedra-like substance known as synephrine that's present in sure citrus fruits, and caffeine. Since stomach acid is irritating, when it refluxes into the throat (which in contrast to the stomach doesn't have tissue designed to resist stomach acid), it often creates the irritating situation often known as heartburn.<br><br>
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